A review of 15 years of data in “Pregnancy”: Prenatal vitamin D supplementation for pregnant women can reduce the risk of asthma and wheezing in children – The first stop for biotech investment – Genet’s perspective

Brigham and Women’s HospitalResearchers recently published a new review paper in the Journal of Allergy and Clinical Immunology, focusing on a study called“Vitamin D Antenatal Asthma Reduction Clinical Trial” (VDAART)common15 years of dataAfter reviewingfound that compared to a standard prenatal multivitaminwomen taking vitamin D supplements during pregnancy can effectively reduce the incidence of asthma and wheezing in children.

Vitamin D is a nutrient that can be obtained through sunlight exposure, diet, or supplements. In addition to being essential for human bone health, vitamin D also plays a key role in autoimmune diseases and other diseases.Researchers stated,Vitamin D deficiency is very common, especially in pregnant women who do not take nutritional supplementsaccording to the results of this retrospective study,It is recommended that all pregnant women should consume at least 4400 IU of vitamin D3 daily from conception throughout pregnancy.

VDAARTClinical trials (clinical trials) mainly recruit10 to 18 weeks pregnant, with a family history of allergies or asthmaPregnant women participated in the study. Half of the pregnant women in the trial took an additional 4400 IU of vitamin D in addition to the 400 IU of vitamin D in the prenatal vitamin. The other half took a placebo and prenatal vitamins. According to the results of the VDAART study,Incidence of asthma at 3 years of age among children born in the treatment groupreduced by 20%only if it hascutoff point for clinical statistical significance,HoweverWhen children reach age 6, the differences between the treatment and control groups become even less significant..

This time, researchers at Brigham and Women’s Hospital used the drug that was part of the original VDAART trial.Vitamin D levels in the control group were stratified and adjustedand successfully seen in observational studiesThe incidence of wheezing and stridor among children in the treatment group was reduced by 50%and published a reanalysis of three-year-old children in “PLoS One” in 2017, and published data on six-year-old children in the “American Journal of Clinical Nutrition” in 2023, further strengthening the relationship between vitamin D and childhood asthma. causal relationship.

However,Why did observational studies show that taking more vitamin D during pregnancy can prevent asthma, but the VDAART clinical trial did not draw a clear conclusion?

In this regard, the researchers explained that because“There is a big difference in design between nutrition trials and drug trials”in drug trials, it is mainly compared“Give drug group”and“No drug group”difference between“More nutrients group”and“Less Nutrient Group”,butThe baseline of the control group is variable.Therefore, understanding the role of nutrients during pregnancy needs to be consideredNutrient dosage, time to start dosingas well asbaseline level in the control groupand other factors, which were not considered in the original VDAART trial.

The researchers also suggested that subsequent relevant clinical trials could start earlier in pregnancy, supplement with 6,000 IU of vitamin D, and recruit a higher proportion of women of color to participate in the trials.

Source: MedicalXPress, Journal of Allergy and Clinical Immunology

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