Reporter Huang Zhongqiu/Taipei Report
▲Huang Limin said that the “chosen person” may just have fewer receptors for the virus (Photo/Provided by National Taiwan University Hospital)
At present, about 1 in 3 people in China are diagnosed, but there are still people who have not been infected by the epidemic so far (20); Huang Limin, a full-time chief physician of the Pediatric Department of National Taiwan University Children’s Hospital, said that they have become “chosen people” It may have fewer receptors for the virus, or it may be related to the cross-protection generated by the improvement of immunity after having been infected with other viruses, but such people are very few and the proportion is not high, and the general public cannot know whether they are the natural choice. The best way to prevent infection is to get vaccinated. Huang Limin believes that the nasal spray vaccine, which is mainly for the protection of the upper respiratory tract mucosa, is the trend of the next generation of vaccines in the future.
It has been nearly 3 years since the global outbreak of the new crown epidemic, but there are still people who have never been infected by the epidemic. According to media reports, many scientists around the world are trying to clarify the reasons for the “chosen people”.
The report pointed out that the team of Mala Maini, professor of viral immunology at University College London, conducted intensive monitoring of medical staff exposed to high-risk environments who should have been infected but did not. A set of blood samples.
Although there are only 10 of these “chosen people” who have never been infected, as many as 6 people have cross-reactive T cells in their trachea. In addition, it has also been discovered internationally that “HLA-B*15:01” is a gene carried by people who are infected but asymptomatic.
Huang Limin, a full-time chief physician of the Pediatric Department of National Taiwan University Children’s Hospital, said that in fact, many people have “chosen people” around them. These people will claim that everyone around them has been diagnosed, and they have not been infected yet, and they all claim to be “chosen people.” , but there is no basis in fact.
Huang Limin said that there may be two conditions to become a “chosen person”, one is that “it has fewer receptors for viruses”; the other is that he may have been infected with other viruses recently. Protect. These are actually similar reports in the past. But this is of little significance to the general public, because the general public cannot know whether they are the chosen person, and there is still a lack of relevant research in China. Therefore, it is best to get vaccinated to prevent infection.
According to foreign reports, Mai Ni is working with a team from Oxford University to study a new vaccine. They said that the T cells in the tracheal mucosa can not only protect people against COVID-19, but also prevent COVID-19 more effectively than vaccines currently on the market. Viruses mutate and spread again.
Huang Limin said that in 2021, the National Taiwan University Hospital team has also started to develop a “nasal spray” vaccine. The difference from the injection vaccine is that in the past, the injection vaccine could only produce IgG antibodies that formed protection against the lower respiratory tract, but still remained in the upper respiratory tract. There will be viruses; in addition to generating IgG antibodies, nasal spray vaccines can also generate IgA antibodies against the upper respiratory tract, which can strengthen the resistance of the respiratory tract. In addition to avoiding severe illness, it can also effectively prevent the spread of the virus.
The National Taiwan University team found from animal experiments that the effect of animal experiments on reducing the amount of virus in the upper respiratory tract is very significant, but Huang Limin revealed that due to the huge demand for human clinical trials, at least nearly 200 million, the domestic vaccine research and development strategy is currently relatively “smooth” It’s natural,” without much subsidy, and in the end, the related plan for human trials originally scheduled to be carried out this year had to fall through. Huang Limin believes that the development of more next-generation vaccines and needle-free nasal spray vaccines will be the future trend.