Taiwan research published on CNN Beirong confirms that the genetic risk of “stubborn depression” is more than 9 times – Free Health Network

[Reporter Qiu Zhirou/Taipei Report]The latest research by the Taipei Rongzong team found that first-degree relatives of patients with “Treatment-resistant depression (TRD)” also have a risk of developing TRD, which is 9.16 times higher than the average person. This is the first article Research confirming the genetic risk of TRD was published in the latest issue of the top international journal in the psychiatric field “JAMA Psychiatry” in April this year, and was also reported in a special article by the international media CNN.

Li Zhengda, director of the Emotional Precision Medicine Center of the Department of Psychiatry, Taipei Wing General Hospital, pointed out that many studies in the past have mentioned that the risk of relatives of patients with mental illness is 1 to 3 times higher than that of the general population. This study also found that some patients with TRD The risk of other relatives, including parents, siblings, children, etc., suffering from other mental diseases, such as anxiety disorder, obsessive-compulsive disorder, depression, bipolar disorder, and even schizophrenia, is also 2 or 3 times higher, but only TRD The risk increased by 9.16 times.

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Li Zhengda said that the first author of this study is Zheng Zhiming, a physician in the Department of Psychiatry. In the past, most people believed that TRD was closely related to “psychological stress”, but more and more evidence shows that there may be a problem with the brain. However, there is still a lack of large-scale research support to determine whether physiological or psychological factors are higher. By analyzing the medical treatment data of Chinese people and connecting different databases, the team confirmed the genetic risk of TRD, which also indirectly supported that TRD has a high degree of biological risk. Sexual causes, that is, more obvious brain abnormalities.

CNN reported that this study analyzed Taiwan’s health insurance database data over a 15-year period. During this period, more than 500,000 Taiwanese were diagnosed with major depression, and among them, they received at least three courses of antidepressant drugs within two years, but There are more than 21,000 TRD patients who have not been successful; Dr. Andrew McIntosh, professor of psychiatry at the Clinical Brain Science Center of the University of Edinburgh in Scotland, bluntly said in an interview that this study proves that TRD has family inheritance. “This is the most convincing evidence so far. “However, in addition to genetic basis, family members may also be affected by shared living environment, socioeconomic disadvantages or other risk factors.

Even the family members of patients do not need to worry too much. Li Zhengda said that not every family member of a TRD patient will become a TRD patient. Due to genetic relationships, the family members of patients may have a low tolerance for stress. As long as they pay more attention to physical and mental adjustment, they will be fine. question. In addition, there are currently many good treatments for TRD. Stimulating the prefrontal lobe through light, electrical therapy or drug therapy can help restore activity to the brain, thereby improving depression symptoms.

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